Endophthalmitis Reduction with Intracameral Moxifloxacin Prophylaxis
Routine intracameral moxifloxacin prophylaxis reduces the overall endophthalmitis.
Haripriya et al. in a retrospective clinical registry study published in Ophthalmology 2017;124:768-775, by the American Academy of Ophthalmology, including 617453 eyes (302815 eyes without moxifloxacin and 314638 eyes with intracameral moxifloxacin) compared the postoperative endophthalmitis rate before and after initiation of intracameral moxifloxacin prophylaxis for both phacoemulsification and sutureless, manual small-incision cataract surgery (M-SICS), as well as in patients with posterior capsular rupture. There was a significant decline in the endophthalmitis rate, from 0.07% to 0.02% (P < 0.001), with moxifloxacin. In addition, PCR increased the endophthalmitis rate nearly seven to 0.48% and IC moxifloxacin reduced the endophthalmitis rate with PCR to 0.21%. No adverse events were noted due to IC moxifloxacin during the study period.